СOMPOSITION

1 ml of the drug contains the active substance (mg): ivermectin – 4 mg;

Additional substances – up to 1 ml.

PACKAGING

Syringe dispenser tubes of 20 ml or 30 ml.

 DESCRIPTION. Homogeneous white gel.

PHARMACOLOGICAL CHARACTERISTICS. ATCvet QP54AA, avermectin (ATCvet QP54AA01, ivermec­tin).

Ivermectin is a 22,23-dihydro derivative of an avermectin (which is a fermentation product produced by Streptomyces avermitilis) and consists of 2 homologues: B1a and B1b.  It is a parasiticide with nematocidal, insecticidal and acaricidal activity documented in a wide range of domesticated animals.

Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action.  Compounds of this class bind selectively and with high affinity to glutamate gated chloride ion channels which occur in invertebrate nerve and muscle cells.  This leads to an increase in the permeability of the cell membrane to chloride ions with the hyper-polarisation of the nerve or muscle cell resulting in paralysis and death of the parasite.

APPLICATION. For the treatment and control of the following species of gastrointestinal roundworms, lungworms, eyeworms, warbles, mites and sucking lice in horses: Ascaridae, Strongylidae, Strongyloididae, Oxyurata, Trihonematidae, Diсtyocаulus spp, Parafilaria multipapillosa, Onchocerca cervicalis  and  larval form  Gasterophilus spp.

DOSAGE. Single doses of 1 ml per 20 kg of bodyweight should be administered orally, using syringe-tube  at the root of the tongue. 

CONTRAINDICATIONS. Do not use for foals up to 4 months of age.

PRECAUTIONS.  Horses must not be slaughtered for human consumption until 28 days after the last treatment.

STORAGE. The drug is stored in a dry, dark place at the temperature from 1°C to 20°C.

Expiration date – 2 years from the date of manufacture