СOMPOSITION

1 ml contains active substances:

praziquantel – 15 mg;

Pyrantel pamoate – 45 mg.

Additional substances: – up to 1 ml

PACKAGING

Polymer bottles of 10 ml, packed in cardboard boxes. Additionally dispos­able syringe with a capacity of 5 ml are put in the box

DESCRIPTION. Suspension of light yellow color. When stor­ing stratification is possible, which disappears after shaking.

PHARMACOLOGICAL CHARACTERISTICS. АТС vet QP52A, anti-distomiasis, anti-nematodosis and anti-cestodiasis veterinary drugs (QP52AA51 – praziquantel, combinations, QP52AF02 – pyrantel).

Pranatan suspension for dogs – anthelmintic broad-spectrum drugs containing active ingredients: praziquantel – derivative of pirazyneizohinoline and Pyrantel pamoate – derivative of tetrahydropirymidine.

Antiparasitic drug effect achieved  by a combination of active substances that exhibit a synergistic effect against adult and larval forms of flat and round worms.

The mechanism of action of praziquantel lies in inhibition of fumarate reductase synthesis on the membranes of myofibrils and neuromuscular synapses, resulting in paralysis and death of helminths.

Pyrantel blocks neuromuscular transmission by depolarization in the sensitive parasites, causing paralysis. The substance has nicotinic properties, acts like acetylcholine inhibits cholin­esterase.

Anti drug effect caused by a combination of components that exhibit synergistic effects on adult and larval forms of flat and round worms.

APPLICATION. Deworming of dogs in case of the next parasitic diseases:

cestodiasis: echinococcosis (mature forms of Echinococcus granulosus), taeniasis (Taenia spp.), dipylidiosis (Dipylidium caninum – young and mature forms), diphyllobothriasis (Di­phyllobothrium latum), mesocestidosis (Mesocestoides spp.);

distomiasis: opisthorchiasis (Opisthorchis felineus);

nematodosis: toxocariasis (Toxocara canis), toxascaridosis (Toxascaris leoninа), trichocephaliasis (Trichuris spp.), ancy­lostomiasis (Ancylostoma caninum), uncinariasis (Uncinaria stenocephala), dirofilariasis (Dirofilaria repens, D. immitis).

DOSAGE. Orally individually with food once or directly upon the root of the tongue with a syringe tube during morning feeding in a dose of 1 ml per 3 kg of body weight.

Treatment is carried out according to indications. In case of a strong degree of invasion deworming is recommended ro repeat after 10 days.

Prophylactic deworming is conducted quarterly and before each vaccination in recomended doses.

Before using a bottle of suspension should be carefully shaken.

Previous starvation diet and the use of laxatives are not nec­essary.

CONTRAINDICATIONS. Do not apply to animals with indi­vidual hypersensitivity to the components of the drug.

Do not apply to puppies up to 2 weeks.

Do not apply the drug to sick and exhausted animals.

PRECAUTIONS. To pregnant females medication can be used 3 weeks before giving birth carefully under the supervi­sion of a doctor of veterinary medicine.

STORAGE. Dry, dark place, away from children at the tem­perature from 0°C to 25°C. Do not store together with food, drinks and animal feeds.

Shelf-life  – 2 years from the date of manufacture.