Clear solution.

Storage

1 ml contains Active substance:

100 mg ketoprofen

Pharmacological properties

Nonsteroidal anti-inflammatory drugs with analgesic action and antipyretic properties.

Pharmacodynamic effect

Ketoprofen belongs to the generation of NSAIDs based on propionic acid.

The agent that causes inflammation, cell damage and activates fosfolipidazy supplying arachidonic acid. This is the basis for enzyme systems tsykloksyhenazy and lipoxygenase, which formed as a result of substances that provoke inflammation: prostaglandins, thromboxanes and leukotrienes. Ketoprofen is a dual inhibitor of inflammation, blocking the path of action and tsykloksyhenazy lipoxygenase and thus preventing the formation of prostaglandins and leukotrienes.

In addition, ketoprofen – is a painkiller that affects the central and peripheral nervous system. Its effect is to direct inhibition of the action of bradykinin, vasodilator and mediator of pain.

In addition to action against bradykinin, ketoprofen is active in the central nervous system, suppressing pain.

Horses ketoprofen endotoxin neutralizing effect and prevents intestinal spasms that cause bradykinin.

Pharmacokinetic data

Ketoprofen is rapidly absorbed. Cows peak plasma levels (8,025 ± 1,9 mg / ml) are reached in less than an hour after intramuscular administration and bioavailability of the substance low. More than 98% bound to plasma proteins and accumulates in inflamed tissues. Ketoprofen has a high affinity with synovial tissues, spreading rapidly and excreted. Duration of the drug longer than expected, according to its half-life, which lasts less than one hour (intravenous horses) to more than five hours (after intramuscular administration to cattle).

Substantial concentrations of ketoprofen found in the synovial fluid and its level is higher than in plasma and elimination half-life is 2-3 times higher than in plasma. Ketoprofen metabolizuyesya insignificant in the liver to biologically active metabolites, and 90% is excreted in the urine as glucuronide compounds.

Application

Cattle – as anti-inflammatory, analgesic and antipyretic for the treatment of inflammation caused by respiratory diseases, breast edema, acute mastitis, inflammation in the musculoskeletal system.

Horses – treatment of inflammatory and pain conditions in diseases of the musculoskeletal system (lameness of traumatic origin, arthritis, arthritis, joint injuries (sprains, synovitis), fractures, tendinitis, hoof lesions (pododermatyt, claudication), inflammation after surgery) ; symptomatic treatment of colic.

Pigs – inflammatory, analgesic and antipyretic therapy in MMA-syndrome, treatment of inflammatory and pain conditions in diseases of the musculoskeletal system; with respiratory infections.

Batching

Cattle, intravenously or intramuscularly 3 ml per 100 kg body weight (3 mg ketoprofen / kg) once a day for 1-3 days.

Horses: IV. For treatment of lesions of bones and joints, and musculoskeletal systems introduce 1 ml per 45 kg of body weight (2.2 mg ketoprofen / kg) once a day for 3-5 days. For symptomatic treatment of colic introduce 1 ml per 45 kg of body weight (2.2 mg ketoprofen / kg body weight) once.

Additional injections carried out only after repeated clinical examination of the animal veterinarians.

Pigs: intramuscular injection 3 ml per 100 kg body weight (3 mg ketoprofen / kg) once a day for 1-3 days.

Contraindication

Contraindicated use of animals with severe renal insufficiency.

Do not enter animals sensitive to ketoprofen.

Reservation

After intramuscular administration may be local swelling, painful when touched, which can swell up to 10 cm in radius and disappears within a week after treatment.

You can not enter the lot mares and foals under 15 days of age.

You can not enter other nonsteroidal anti-inflammatory drugs, diuretics or anticoagulants.

Consumption of milk in the food people are allowed without restrictions

Slaughter of animals for meat is allowed 4 days after the last injection.

Product

Brown bottle with a transparent hydrolytic glass 10, 100 ml.

Storage

Dry dark place at a temperature of 5 ° C to 25 ° C.

Shelf life – 2 years from date of manufacture. Open a bottle to use for 7 days.