The solution was yellowish.

Storage

1 ml contains active ingredients:

sulfametazyn 200 mg;

trimethoprim 40 mg;

Pharmacological properties

Sulfametazyn – a synthetic chemotherapeutic agent from the group of sulphonamides. Trimethoprim is a synthetic chemotherapeutic agent, a derivative dyaminopirymidynu.

Separately, each component has a bacteriostatic effect, but sulfametazyn and trimethoprim, taken in the ratio 4: 1, increase the effect of each other and have a bactericidal nature of the drug.

Such synergy is manifested by the fact that the components affecting two successive processes that are necessary for the synthesis of acid or bacterial tetrahidrofoliyevoyi folinovoyi acid, which plays a major role in the synthesis of purines bacteria. The bacterial wall is impermeable to folate, so purine synthesis depends on their own ability synthesizing microorganisms.

The effect of these two components is as follows:

– Sulfametazyn, in its chemical characteristics similar with p-aminobenzoic acid and with it participates in the enzyme dyhidropteroilsyntetazy, counteracting the formation dyhidrofoliyevoyi acid;

– Trimethoprim blocks the next link in the chain of biosynthetic, braking effect dyhidrofolatoreduktazy – an enzyme that accelerates transformation dyhidrofoliyevoyi acid tetrahidrofoliyevu.

The combination of these components provides a chemotherapeutic drug bactericidal activity. Thus the emergence of strains that are resistant to the drug, is negligible.

The combination of trimethoprim-sulfametazyn has a broad spectrum of activity covering Gram-positive and Gram-negative bacteria. By microorganisms which are very sensitive to the drug, include the following bacteria: Escherichia coli, Clostridium spp., Shigella spp., Salmonella spp., Proteus mirabilis, Bacillus anthracis, Pasteurella spp., Haemophilus influenzae, Haemophilus gallinarum, Vibrio spp., Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus faecalis, Streptococcus virulam, Streptococcus agalactiae, Staphylococcus aureus, Proteus spp. and Brucella spp.

Application

Cattle: Treatment of animals suffering from kolibakteriozni and Salmonella gastroenteritis, vibrioz, pneumonia, septicemia, pasteurellosis, streptokokozni, stafilokokozni and kolibakteriozni mastitis, actinomycosis, purulent abscesses, as well as diseases of the genitourinary system, caused by pathogens susceptible to sulfametazymu and trimethoprim.

Horse: treatment of animals suffering from diarrhea, pneumonia, pioseptytsemiyu, caused by pathogens susceptible to trimethoprim and sulfametazymu.

Pigs: treatment of animals suffering from colibacillosis, salmonellosis, vibrioznu dysentery, pneumonia, pasteurellosis, malignant edema, abscess, caused by pathogens susceptible to trimethoprim and sulfametazymu.

Sheep, goats, treatment of animals suffering from colibacillosis, salmonellosis, vibrioznu dysentery, pneumonia, enteritis, abscesses, mastitis, caused by pathogens susceptible to trimethoprim and sulfametazymu.

Dogs, cats: treatment of animals suffering from pulmonary infections, septicemia, bacterial enteritis, coccidiosis in dogs caused by pathogens susceptible to trimethoprim and sulfametazymu.

Batching

Intramuscular dose of 1 ml per 10 kg of body weight daily for 3-5 days. On the first day of treatment the daily dose divided into two parts and administered at intervals of 12 hours.

Contraindication

Hypersensitivity to sulfonamides. Do not use in animals with renal or hepatic impairment. Do not use with folate and p-aminobenzoic drugs

Reservation

Slaughter of animals for meat is permitted in 28 days after the last use of the drug. Consumption of milk in the food people are allowed after 4 days after the last use of the drug. Received by the deadline of meat and milk, or utilize unproductive animals are fed, according to a doctor of veterinary medicine.

Product

Brown bottle with a transparent hydrolytic glass, closed with a rubber stopper under an aluminum run of 100 ml.

Storage

Dry, dark, place inaccessible to children at temperature from 5 ° to 25 ° C.

Shelf life – 5 years from date of manufacture.