СOMPOSITION

1 g of the drug contains the active sub­stances: ivermectin – 3.5 mg.

excipients: up to 1 g.

PACKAGING

Triplex or polymeric packages of 10, 50, 100, 500 and 1000 g.

DESCRIPTION. Microgranules of 2-4 mm in diameter, of pale yellow color, odorless, with pleasant slightly sweet taste.

PHARMACOLOGICAL CHARACTERISTICS code vet QP54AA, avermectin (ATCvet QP54AA01, ivermectin) Ivermectin (22,23-dyhydroavermectin B1) .

Ivermectin is a 22,23-dihydro derivative of an avermectin (which is a fermentation product produced by Streptomyces avermitilis) and consists of 2 homologues: B1a and B1b.  It is a parasiticide with nematocidal, insecticidal and acaricidal activity documented in a wide range of domesticated animals.

Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action.  Compounds of this class bind selectively and with high affinity to glutamate gated chloride ion channels which occur in invertebrate nerve and muscle cells.  This leads to an increase in the permeability of the cell membrane to chloride ions with the hyper-polarisation of the nerve or muscle cell resulting in paralysis and death of the parasite.

APPLICATION. Treatment of nematode or arthropod infections of pigs, poultry (chickens, turkeys, ducks, geese), rabbits, dogs and cats due to:

pigs . mature and larval forms of nematodes families Ascaridae, Metastrongylidae, Oligacanthorhynchidae, Ollulanidae, Strongyloididae, Trichonematidae, Trichuridae; with lesions of ticks of the species Demodex phylloides, Sarcoptes parvula, Sarcoptes suis and lice of type Haematopinus suis;

poultry (chickens, turkeys, geese, ducks) . nematodes of families: Ascaridae, Amidostomatidae, Capillariidae, Dioctophymidae, Heterakidae, Syngamidae, Tetrameridae; with lesions of ectoparasites: ticks of species Argas persicus, Dermanyssus gallinae, Epidermoptes bilobatus, Knemidocoptes gallinae, K. mutans, „K. pilae, Syringophilus bipectinatus; various lice, fleas and bird-lice, the most pathogenic species are: Menopon gallinae, Menacanthus stramineus, Goniodes hologaster, Lipeurus caponis, Echilnophaga gallinacean, Ceratophyllus gallina;

rabbits . nematodes of the families Oxyuridae, Strongyloidae, Trichostrongylidae; with lesions of ticks Psoroptes cuniculi, Cheyletiella parasitivorax, Listrophorus gibbus „„„p „q„|„€„‡„p„}„y Spilopsyllus cuniculi . the main carriers of myxomatosis;

carnivores (dogs, cats) . nematodes of families Anisacidae, Ancylostomatidae, Ascaridae, Capillariidae, Filariidae, Thelaziidae, Trichuridae; with lesions of ticks Cheyletiella jasguri, Demodex canis, Notoedres cati, Otodectes cynotis, Sarcoptes canis skin parasites of types Ctenocephalides canis, Linognathus setotus, Trichodectis canis.

DOSAGE. The drug is primarily intended for use by the group method.

To ensure thorough dispersion of the product it should first be mixed with a suitable quantity of feed ingredients before incorporation in the final mix.

For pigs on rearing and fattening drug is used at a dose of 2 g/10 kg of body weight. Calculated for livestock dose is mixed with 7 daily rations of feed and feedstuffs, the  treatment is conducted during  7 days under the established type  of feeding.

For dogs and cats drug is used at the rate of 2 g/10 kg of bodyweight, calculated dose is divided into 3 parts  and fed with minced meat for 3 days. Single use of the drug in the same doses is possible.

For poultry (chickens, turkeys, ducks, geese) and rabbits drug is used at a dose of 1 g/10 kg of body weight. The calculated dose for group (herd) is mixed with 3 daily norm feed and fed for three days. In the presence of ectoparasites a week after the first course of treatment repeat the treatment with same doses. At the same time it is necessary to make a disinsection of the building.

CONTRAINDICATIONS. Do not use for dogs of small breeds and puppies under 6 months of age.

APPLICATION. To ensure thorough dispersion of the product it should first be mixed with a suitable quantity of feed ingredients before incorporation in the final mix..

Slaughter for human consumption of pigs, rabbits and poultry for meat is allowed 15 days after the last administration of the drug. Eggs obtained from hens during their drug treatment, are not allowed to use for human consumption, it can be used only after 7 days from the last treatment.

STORAGE. Dry, dark place at the temperature from -10‹C to +25‹C.

Shelf-life. 3 years from the date of manufacture.