DESCRIPTION.

Oily suspension of white color with a specific smell.

PHARMACOLOGICAL CHARACTERISTICS.

Procaine penicillin is a bactericidal antibiotic of penicillin group, that acts on gram-positive and gram-negative bacteria: Campylobacter spp., Clostridium spp., Corynebacterium spp., Erysipelothrix  spp.,  Actinobacillus  spp.,  Haemophilus spp., Listeria spp., Pasteurella spp., Staphylococcus spp., Streptococcus spp. Its mechanism of action provides violation  of  peptidoglycan  synthesis  –  mucopeptide  of  cell membrane that leads to inhibition of microorganism cell wall synthesis, inhibition of bacteria growth.

Streptomycin sulfate belongs to a subgroup of streptomycin and to a group of natural aminoglycosides and is an antibiotic with bactericidal antimicrobial action type. The substance acts on bacteria that are in the stage of reproduction and somewhat weaker on microbes in the resting stage. Bactericidal action of antibiotic is realized by inhibiting of protein synthesis of microbial cells. Streptomycin sulfate has  antimicrobial  activity  against  many  gram-positive and gram-negative bacteria, including acid and penicillin-resistant forms, inhibiting the growth of most bacteria, which belong to the genus Staphylococcus, Streptococcus, Brucella, Klebsiella, Mycobacterium, Neiseria, Pasteurella, Salmonella, Shigella, Haemophilus, etc.

In center of an inflammation under the influence of streptomycin is reduced edema and infiltration, is accelerated the transition of exudative reaction to productive.

Neomycin sulfate belongs to a neomycin subgroup and to a group of natural aminoglycosides formed by actinomycetes.

Neomycin – antibiotic with a broad spectrum of antimicrobial activity. It is active against many gram-negative bacteria and cocci (E.coli, genera Salmonella, Shigella, Meningococcus),  and  gram-positive  bacteria  (Staphylococcus  aureus,  Streptococcus  agalactiae,  Streptococcus  dysgalactiae,  Enterococcus  spp.).  Bactericidal action  of  antibiotic,  as  well  as  other  members  of  the aminoglycosides group is realized by inhibiting of protein synthesis of microbial cells.

Prednisolone  is  a  dehydrated  analogue  of  hydrocortisone. It has properties inherent to other compounds of this  group,  namely:  has  anti-inflammatory,  anti-allergic and desensitizing effect, antishock and antitoxic properties. Stimulating steroid receptors, it induces the formation of a special class of proteins – lipocortins that have anti-edema activity and also reduces the activity of hyaluronidase and reduces the permeability of capillaries.

APPLICATION.

Treatment of cows various forms of mastitis of bacterial etiology during lactation.

DOSAGE.

The contents of one syringe tube inject into share of the affected breast, which previously milk and disinfect. After the injection quarter of breast massage for  uniform  distribution  throughout  the  tank.  Repeated application is carried out every 24 hours for 3 days.

CONTRAINDICATIONS.

Do not use the drug to animals susceptible to penicillin and aminoglycoside group.

PRECAUTIONS.

Slaughter of animals for meat is permitted in 7 days after the last injection. The use of milk in food by people is allowed in 108 hours after the last drug application. Obtained by the deadline meat and milk fed to unproductive animals or utilize (depending on a conclusion of doctor of veterinary medicine).

STORAGE.

Dry, dark, inaccessible to children at temperature from 15°C to 25°C.

Expiration date – 2 years from date of manufacture.

PACKAGING

Syringes intramammary (syringe tubes) 5 g, packed in a polymeric package.

СOMPOSITION

1 syringe tube (5 g) contains active substances:

procaine penicillin – 100 000 IU;

streptomycin sulfate – 100 mg;

neomycin sulfate – 100 mg;

prednisolone – 10 mg;

Excipients – up to 5 g.

Antimastitis agents 256