Oily  suspension  of  light  yellow  color with a specific smell.

PACKAGING

Syringes intramammary (syringe tubes) 5 ml, packed in polymeric package, glass bottles 50, 100 ml.

СOMPOSITION

1 dose (5 ml) contains active substances: benzyl penicillin sodium salt – 100,000 IU; streptomycin sulfate – 0.1 g; sulfadimine- 0,35g.

PHARMACOLOGICAL  CHARACTERISTICS. Mast BSS  –  a  combined  anti-mastitis  drug,  which  includes sodium  benzyl  penicillin,  streptomycin  sulfate  and  sulfadimine.

Benzylpenicillin sodium salt is a drug of penicillins series, which has bactericidal action against gram-positive and some gram-negative organisms, including Staphylococcus  spp.,  Streptococcus  spp.,  Pneumococcus spp.,  Diplococcus  spp.,  Spirochaeta  spp. and  others. This action is based on inhibition of the biosynthesis of microorganisms cell wall, which forms the basis of complex heteropolymer peptidoglycan.

Streptomycin  sulfate  belongs  to  a  streptomycin  subgroup  and  natural  aminoglycosides  droup  and  is  an antibiotic with bactericidal antimicrobial action type. The active  substance  active  against  microorganisms  that are in the stage of reproduction, and somewhat weaker against bacteria in the resting stage. Bactericidal action of antibiotics is realized by inhibiting of protein synthesis of microbial cells. Streptomycin sulfate is active against many  gram-positive  and  gram-negative  bacteria,  including acid and penicillin-resistant strains, inhibits the growth and development of Staphylococcus spp., Streptococcus spp., Brucella spp., Klebsiella spp., Mycobacterium spp., Neisseria spp., Pasteurella spp., Salmonella spp., Shigella spp., Haemophilus spp.and others.

In  inflammation  under  the  influence  of  streptomycin  is reduced edema and infiltration, is accelerated the transition of exudative reaction in productive.

Sulfadimine  –  a  substance  from  the  group  of  sulfonamides.  At  therapeutic  concentrations  sulfonamides have bacteriostatic effect against sensitive microorganisms. They belong to the chemotherapeutic agents with a broad spectrum of antibacterial action, inhibit the life activity  of  many  species  of  gram-positive  and  gramnegative  microorganisms:  streptococci,  staphylococci, meningococci and many others.

APPLICATION. Treatment of cows with clinical and subclinical forms of mastitis caused by susceptible microorganisms to the components of the drug, during lactation.

DOSAGE. Intramammary. Before injection of the drug affected share of the udder carefully milk and conduct aseptic  processing  of  breast.  The  pre-heated  to  36-38°C  and  shaked  homogeneous  solution  is  slowly  injected into dairy feed directly from the syringe tube using a syringe and milk catheter. After injection conduct light massage of udder share from top to bottom. The drug is injected twice daily with intervals of 12 hours at a dose:

– The treatment of serous and sero-catarrhal mastitis – 5 ml per injection;

– The treatment of catarrhal, purulent-catarrhal, purulent and purulent-hemorrhagic mastitis – 10 ml per injection.

The course of treatment – 3-5 days.

CONTRAINDICATIONS. Do not use the drug in a dry period.Do  not  apply  to  animals  with  hypersensitivity  to the active ingredients of the drug.

PRECAUTIONS. During the treatment and for 3 days after the last injection milk from the affected udder share milk  in  a  separate  bowl  and  recycle;  milk  from  healthy udder shares fed to animals after boiling. Use meat from slaughtered animals during treatment is permitted without restrictions except the udder, which is discarded.

STORAGE. Dry, dark, inaccessible to children at temperature from 0°C to 20°C.

Expiration date – 18 monthsfrom date of manufacture.