The powder is white or white with a slightly yellowish tint.

PHARMACOLOGICAL CHARACTERISTICS. Bitsinovet-5 is a bactericidal antibiotic that belongs to the group of peni­cillins, which are sensitive to the action of β-lactamases. The medicine inhibits the formation of peptide bonds by inhibiting of transpeptidase, violates the later stages of peptidoglycan syn­thesis of the cell membrane, leading to lysis of cells that divide.

Bitsinovet-5 is active against gram-positive bacteria, including the Streptococcus spp. (including Streptococcus pneumoni­ae), Staphylococcus spp. (except penicillinase producing), Bacillus spp., lister (L. monocytogenes), erysipelothrix (E. rhu­siopathiae), most corynebacteria and anaerobic bacteria (acti­nomycetes, Peptostreptococcus spp., Clostridium spp.), spiro­chetes (Treponema spp., Borrelia spp., Leptospira spp.). Most gram-negative bacteria, protozoa, viruses, fungi, and rickettsia are not sensitive to the medicine. Since gram-negative bacte­ria are sensitive to the drug only Neisseria spp., Pasteurella multocida, H. dugreyi.

APPLICATION. Treatment of cattle, sheep, goats, pigs, horses, foxes, minks and dogs from necrobacillosis, pasteurellosis, pneumonia, mastitis, metritis, wound infection, otitis media, septicemia, cellulitis; actinomycosis, blackleg; streptococcal septicemia of cattle, sheep and goats; horses strangles, stachybotryotoxicosis, streptococcosis, staphylo­coccsis, infectious stomatitis, rhinitis, plague of dogs and fur animals, swine erysipelas, and in diseases of the urinary tract, caused by microorganisms sensitive to benzylpenicillin.

DOSAGE. Suspension for injection is prepared sterile imme­diately before the application. Bitsinovet-5 after the addition of 9 ml of isotonic sodium chloride solution or sterile water for injection, or 0.25-0.5% solution of novocaine must be shaken up to a homogeneous mixture. The medicine is injected intra­muscularly once every 10-15 days at a dose given in the table.

CONTRAINDICATIONS. Hypersensitivity to agents of the penicillin or novocaine group. Do not apply to guinea pigs and hamsters.

PRECAUTIONS. Before the application of the medicine a preliminary intradermal test for tolerability should be done! Bitsinovet-5 is injected only intramuscularly! Intravenous medi­cine is forbidden!

The suspension is prepared sterile immediately before the application. The slaughter of animals for meat and milk con­sumption in the food of people is allowed, respectively, in 20 days and 10 days after the last injection of the drug. Received by the deadline meat and milk utilize or feed to un­productive animals, according to the local legislation base.

Do not mix Bitsinovet-5 solution with other injectable solutions.

In case of application with bactericidal antibiotics (including cephalosporins, cycloserine, vancomycin, rifampicin, amino­glycosides) synergistic effects are observed; with bacterio­static antibiotics (including macrolides, chloramphenicol, lin­cosamides, tetracycline) – antagonism.

Not recommended to combine with non-steroidal and anti-inflammatory drugs. Benzylpenicillin reduces clearance and increases the toxicity of methotrexate.

STORAGE. Dry, dark, unreachable for children place at tem­perature from 5°С tо 25°С. To store the medicine separately from food, drinks, including the animal feed.

SHELF – LIFE  – 3 years.