Homogeneous powder of light yellow color with a weak specific smell.

Storage

1 g of the drug contains the active substance:

sulfadimetoksina sodium – 300 mg;

sulfadyazyn sodium – 300 mg;

trimethoprim – 120 mg.

The product comes with an additional vial with solvent (sodium chloride solution

0.9%).

Pharmacological properties

The mechanism of action of the drug containing sulfonamides and trimethoprim, is blocking two enzymes successive stages of biosynthesis of folic acid in bacterial cell. This leads to the inhibition of bacteria growth, reproduction and termination of their death.

The combination of the two original dyaminopirymidynu and sulfonamides (trimethoprim) gives a synergistic effect which extends the antimicrobial spectrum of activity against Gram-positive drug and gram-negative bacteria (Staphylococcus spp., Streptococcus spp., Neisseria spp., Clostridium spp., Listeria monocytogenes, Corynebacterium spp., E. coli, Salmonella spp., Klebsiella spp., Proteus spp., Citrobacter spp., Pasteurella spp., Bordetella spp, Enterobacter spp., Yersinia enterocolitica, Chlamidya spp., Vibrio cholerae, etc.). By components of the drug are also sensitive some protozoa (Pneumocystis carinii, Coccidia and Toxoplasma).

This combination of sulfonamides and trimethoprim reduces the likelihood of resistant forms of pathogenic organisms.

Application

Treatment of cattle, sheep, goats, horses, pigs, rabbits, dogs, cats and poultry (chickens, turkeys, ducks, geese) diseases of gastrointestinal tract (gastritis, enteritis, dyspepsia), respiratory (tonsillitis, tracheitis, pharyngitis , bronchopneumonia, pleurisy) and genitourinary (postpartum sepsis, cystitis, urethritis, endometritis), postoperative complications, mastitis, actinomycosis, erysipelas, dysentery, dyplokokozu, enterotoxemia eymeriozu, esheryhiozu (colibacillosis), washed, pasteurellosis, pulorozu, oedematous disease mycoplasmosis, salmonellosis, caused by pathogens susceptible to sulfadimetoksina, sulfadyazynu and trimethoprim.

Batching

Intramuscular doses:

cattle, sheep, goats, horses, pigs – 0.6-0.8 ml per 10 kg body weight;

dogs, cats – 0.1-0.15 ml per 1 kg of body weight;

poultry (chickens, turkeys, ducks, geese), rabbits – 0.1 ml per kg body weight.

Repeated administration carried out 3-5 times at intervals of 24-36 hours. The recommended course of treatment – 5 days. In cases of incomplete disappearance of clinical signs of the period of application extend for another 2 days.

Large animals allowed vnutrishnoaortalne or slow intravenous administration.

For the treatment of young poultry, pigs and rabbits may be used inside drinking water. For this preparation solution is added to the daily requirement of drinking water at a rate of 1 ml 0,9-1,2 liters of drinking water (1 g of powder in 3 liters of water).

In one place the injection of young and small animals should be given no more than 10 ml, and adult animals – not more than 20 ml of the drug.

Contraindication

Hypersensitivity to the drug. Do not assign to animals with impaired renal function and liver.

Reservation

For the cultivation of the drug not be used novocaine solution.

Goats have increased sensitivity to sulfonamides because they introduce a solution of the drug should be used with caution.

Slaughtering of animals and poultry for meat is permitted in 10 days, milk and egg consumption in the food people – 4 days after the last use of the drug. Received by the deadline of meat, milk and eggs or utilize unproductive animals are fed, according to a doctor of veterinary medicine.

Product

Glass bottles, closed with a rubber stopper under an aluminum run on 3.3 and 6.6 grams complete with sterile 0.9% sodium chloride for 8 and 16 ml respectively.

Storage

Dry, dark, place inaccessible to children at temperature from 0 ° C to 25 ° C.

Shelf life – 2 years from date of manufacture.

After making solvent resulting solution should be used within a day, and provided cold storage – within three days after preparation.