Description

White cream.

Composition

1 g of the drug contains active substances (mg):

betamethasone dipropionate 0.64;

gentamicin sulfate 1.0;

clotrimazole 10.0.

Excipients: – up to 1g.

Pharmacological characteristic

Thanks to a combination of active ingredients drug has anti-inflammatory, anti-allergic, antibacterial, antifungal actions.

Betamethasone dipropionate – a synthetic fluorine-consisting corticosteroid. It has anti-inflammatory, glucocorticoid, anti-allergic, antipruritic actions. In case of external application narrows blood vessels, eliminates itching, slows excretion of inflammatory mediators (eosinophils, mast cells), interleukins 1 and 2, γ-interferon (from lymphocytes and macrophages), inhibits the activity of hyaluronidase and reduces the permeability of vessel walls.

Clotrimazole belongs to the group of imidazole antifungal drugs. Increases the permeability of the phospholipid  membrane of liposomes, vacuolization of cytoplasm, reduction of the number of ribosomes. Clotrimazole is active in relation to: Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum sapis, Candida alvicans, Malassezia furfur (Pityrosporum orbiculare).

Gentamicin – broad-spectrum antibiotic of the aminoglycoside group that acts bactericidal on gram-negative bacteria: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae; gram-positive bacteria: Streptococcus spp., Staphylococcus aureus.

In case of cutaneous application of the drug San D in therapeutic doses transdermal absorption of active substances in the blood is very low. Application of occlusive bandages significantly enhances transdermal absorption of gentamicin and betamethasone, which can lead to increase of risk of systemic side effects.

Application

For the treatment of dogs and cats dermatitis with severe allergic, inflammatory reaction, pruritus, hyperemia, edema, infiltration, complicated by secondary bacterial infection; fungal skin diseases caused by Microsporum canis, Trichophytop rubrum, Trichophyton mentagrorhytes, candidiasis caused by Candida albicans, Candida parapsilosis, lesions by yeast fungi Malassezia furfur.

Dosage

Cream use externally, locally. Dose of the drug depends on the area of the affected skin. Before applying the cream cut hair on the affected area . The cream should be applied on the affected skin and surrounding area with a thin layer 2 times a day (morning and evening), gently rubbing into the skin. After achieving of clinical improvement, frequency of application of the drug can be reduced to 1 time per day.

The duration of treatment is determined by the elimination of inflammation process and negative data of bacterial and/ or mycological analysis, by termination of itching, skin cleansing.

The course of treatment depends on the type and severity of disease and the effectiveness of therapy and is determined by doctor of veterinary medicine and usually lasts 2-4 weeks (maximum); between repeated courses necessary a break lasting at least 20 days.

Contraindications
Hypersensitivity to the components of the drug.

Side effects

Excessive and prolonged application of the drug on large areas of skin can lead to the appearance of systemic effects inherent for application glucocorticosteroids, namely the inhibition of the hypothalamic-pituitary-adrenal system with the development of secondary adrenal insufficiency, symptoms of hypercorticism (weight gain, edema, hypertension, glycosuria, hypokalemia), the occurrence of Cushing’s syndrome

Precautions

Avoid getting

of the drug in eyes, open wounds.

Do not apply cream on the skin around eyes.

Form of packaging

Рolymeric banks 20 g

Storage

In original packaging at temperature not above 25 ° C. Do not freeze.

Expiration date

3 years from date of manufacture.