{"id":1978,"date":"2018-02-15T18:17:43","date_gmt":"2018-02-15T15:17:43","guid":{"rendered":"https:\/\/agroolkar.com.ua\/?post_type=production&p=1978"},"modified":"2023-10-09T14:28:51","modified_gmt":"2023-10-09T11:28:51","slug":"bytsynovet-5","status":"publish","type":"production","link":"https:\/\/agroolkar.com.ua\/en\/production\/bytsynovet-5\/","title":{"rendered":"Bicinovet-5"},"content":{"rendered":"

QUALITATIVE AND QUANTITATIVE COMPOSITION<\/strong><\/p>\n

1 flask contains active agents:<\/p>\n

Benzathine benzylpenicillin sterile \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a01\u00a0271.19 mg;<\/p>\n

Benzylpenicillin novocaine\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 317.80 mg;<\/p>\n

    \n
  1. \u041a\u041b\u0406\u041d\u0406\u0427\u041d\u0406 \u0425\u0410\u0420\u0410\u041a\u0422\u0415\u0420\u0418\u0421\u0422\u0418\u041a\u0418<\/strong><\/li>\n<\/ol>\n

    4.1 <\/strong>Therapeutic<\/strong> indications<\/strong><\/p>\n

    Treatment of cattle, sheep, goats, pigs, horses, foxes, minks and dogs from necrobacillosis, pasteurellosis, pneumonia, mastitis, metritis, wound infection, otitis media, septicemia, cellulitis; actinomycosis, blackleg; streptococcal septicemia of cattle, sheep and goats; horses strangles, stachybotryotoxicosis, streptococcosis, staphylo\u00adcoccsis, infectious stomatitis, rhinitis, plague of dogs and fur animals, swine erysipelas, and in diseases of the urinary tract, caused by microorganisms sensitive to benzylpenicillin.<\/p>\n

    4.2 Posology and method of administration <\/strong><\/p>\n

    Do not mix Bicinovet-5 solution with other injectable solutions.<\/p>\n

    In case of application with bactericidal antibiotics (including cephalosporins, cycloserine, vancomycin, rifampicin, amino\u00adglycosides) synergistic effects are observed; with bacterio\u00adstatic antibiotics (including macrolides, chloramphenicol, lin\u00adcosamides, tetracycline) \u2013 antagonism.<\/p>\n

    Not recommended to combine with non-steroidal and anti-inflammatory drugs. Benzylpenicillin reduces clearance and increases the toxicity of methotrexate.<\/p>\n

     <\/p>\n

    Suspension for injection is prepared sterile imme\u00addiately before the application. Bicinovet-5 after the addition of 9 ml of isotonic sodium chloride solution or sterile water for injection, or 0.25-0.5% solution of novocaine must be shaken up to a homogeneous mixture. The medicine is injected intra\u00admuscularly once every 5 days at a dose given in the table.<\/p>\n

     <\/p>\n\n\n\n\n\n\n\n\n\n\n
    Animals type <\/strong><\/td>\nProduct doses (mg per 1 kg of body weight)<\/strong><\/td>\n<\/tr>\n
    Adult <\/strong><\/td>\nYoungsters <\/strong><\/td>\n<\/tr>\n
    Cattle<\/td>\n9.91 mg\/1 KG BWG<\/td>\n14.87 mg\/1 KG BWG<\/td>\n<\/tr>\n
    Sheep, goats<\/td>\n14.87 mg\/1 KG BWG<\/td>\n19.82 mg\/1 KG BWG<\/td>\n<\/tr>\n
    Pigs<\/td>\n9.91 mg\/1 KG BWG<\/td>\n19.82 mg\/1 KG BWG<\/td>\n<\/tr>\n
    Horses<\/td>\n14.87 mg\/1 KG BWG<\/td>\n19.82 mg\/1 KG BWG<\/td>\n<\/tr>\n
    Foxes, minks and arctic foxes<\/td>\n39.64 mg\/1 KG BWG<\/td>\n49.55 mg\/1 KG BWG<\/td>\n<\/tr>\n
    Dogs<\/td>\n99.11 mg\/1 KG BWG<\/td>\n–<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

     <\/p>\n

    4.3 Contradictions<\/strong><\/p>\n

    Hypersensitivity to agents of the penicillin or novocaine group. Do not apply to guinea pigs and hamsters.<\/p>\n

     <\/p>\n

    4.4 Special warnings and special precautions for use<\/strong><\/p>\n

    Before the application of the medicine a preliminary intradermal test for tolerability should be done! Bicinovet-5 is injected only intramuscularly! Intravenous medi\u00adcine is forbidden!<\/p>\n

    The suspension is prepared sterile immediately before the application.<\/p>\n

     <\/p>\n

    4.5 Interaction with other FPPs and other forms of interaction<\/strong><\/p>\n

    Do not mix Bicinovet-5 solution with other injectable solutions.<\/p>\n

    In case of application with bactericidal antibiotics (including cephalosporins, cycloserine, vancomycin, rifampicin, amino\u00adglycosides) synergistic effects are observed; with bacterio\u00adstatic antibiotics (including macrolides, chloramphenicol, lin\u00adcosamides, tetracycline) \u2013 antagonism.<\/p>\n

    Not recommended to combine with non-steroidal and anti-inflammatory drugs. Benzylpenicillin reduces clearance and increases the toxicity of methotrexate.<\/p>\n

     <\/p>\n

    4.6 <\/strong>Pregnancy<\/strong> and<\/strong> lactation<\/strong><\/p>\n

    Product can be applied to animals during lactation and pregnancy.<\/p>\n

    4.9 \u041f\u0435\u0440\u0435\u0434\u043e\u0437\u0443\u0432\u0430\u043d\u043d\u044f<\/strong><\/p>\n

    Penicillin belongs to low-toxic combinations and during any type of clinical application causes no side effects.<\/p>\n

    Rare: hypersensibility, skin rash, itch, arthralgia, edema, acute anaphylaxis and urticaria fever.<\/p>\n

    Respiratory system: bronchismus<\/p>\n

    Digestive system: canker, diarrhea, compromised liver function<\/p>\n

    Genitourinary apparatus: interstitial nephritis<\/p>\n

     <\/p>\n

      \n
    1. PHARMACOKINETIC PROPERTIES <\/strong><\/li>\n<\/ol>\n

      ATC vet QJ01<\/p>\n

      Anti-infective\u00a0 veterinary drugs for extensive use.<\/p>\n

       <\/p>\n

      5.1 Pharmacodynamics properties <\/strong><\/p>\n

      Bicinovet-5 is a bactericidal antibiotic that belongs to the group of peni\u00adcillins, which are sensitive to the action of \u03b2-lactamases. The medicine inhibits the formation of peptide bonds by inhibiting of transpeptidase, violates the later stages of peptidoglycan syn\u00adthesis of the cell membrane, leading to lysis of cells that divide.<\/p>\n

      Bicinovet-5 is active against gram-positive bacteria, including the\u00a0Streptococcus spp.\u00a0<\/em>(including\u00a0Streptococcus pneumoni\u00adae<\/em>), Staphylococcus spp. (except penicillinase producing),\u00a0Bacillus spp.,\u00a0<\/em>lister (L. monocytogenes<\/em>), erysipelothrix (E. rhu\u00adsiopathiae<\/em>), most corynebacteria and anaerobic bacteria (acti\u00adnomycetes,\u00a0Peptostreptococcus spp., Clostridium spp.<\/em>), spiro\u00adchetes (Treponema spp., Borrelia spp., Leptospira spp.<\/em>). Most gram-negative bacteria, protozoa, viruses, fungi, and rickettsia are not sensitive to the medicine. Since gram-negative bacte\u00adria are sensitive to the drug only\u00a0Neisseria spp., Pasteurella multocida, H. dugreyi.<\/em><\/p>\n

       <\/p>\n

      5.2 Pharmacokinetic properties <\/strong><\/p>\n

      When product is given by intramuscular injection to animals, it forms a depot from which it is slowly released and hydrolysed to benzylpenicillin. Peak plasma concentrations are produced in 1 to 4 hours, and effective concentrations of benzylpenicillin are usually maintained for 12 to 24 hours. However, plasma concentrations are lower than those after an equivalent dose of benzylpenicillin novocaine.<\/p>\n

      5.3 <\/strong>Preclinical<\/strong> safety<\/strong> data<\/strong><\/p>\n

      After treatment course of rabbits, sick of clinical and subclinical mastitis, usage of Bicinovet-5 caused recuperation of all animals with milk production recovery.<\/p>\n

      Usage of Bicinovet-5 to cows caused no side effects on morphofunctional body state of animals.<\/p>\n

      Product clinical trials approved its efficiency as \u0441hemotherapeutic drug for treatment of clinical and subclinical forms of cows mastitis.<\/p>\n

        \n
      1. PHARMACEUTICAL<\/strong> PARTICULARS<\/strong><\/li>\n<\/ol>\n

         <\/p>\n

        6.3 <\/strong>Shelf<\/strong> life<\/strong><\/p>\n

        3 years from manufacture date.<\/p>\n

        6.4 Special precautions for storage <\/strong><\/p>\n

        Dry, dark, place inaccessible to children at temperature from 5 \u00b0C to 25 \u00b0C.<\/p>\n

        Do not store together with food, beverages, including animal feeds<\/p>\n

         <\/p>\n

        6.5 Nature and contents of container <\/strong><\/p>\n

        Glass flasks, closed with rubber corks under aluminium rolling up per 1\u00a0588.98 mg.<\/p>\n

         <\/p>","protected":false},"featured_media":1979,"template":"","meta":{"_acf_changed":false},"product":[63,61,4,57,10,56,60,59,3,58,50],"class_list":["post-1978","production","type-production","status-publish","has-post-thumbnail","hentry","product-grizuni","product-verblyudi","product-veterinarni-preparati","product-vivtsi","product-inyektsijni-protimikrobni-zasobi","product-kozi","product-koni","product-korovi","product-produktsiya","product-svini","product-sobaki"],"acf":[],"yoast_head":"\nBicinovet-5 - O.L.KAR<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/agroolkar.com.ua\/en\/production\/bytsynovet-5\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bicinovet-5 - O.L.KAR\" \/>\n<meta property=\"og:description\" content=\"QUALITATIVE AND QUANTITATIVE COMPOSITION 1 flask contains active agents: Benzathine benzylpenicillin sterile \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a01\u00a0271.19 mg; Benzylpenicillin novocaine\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 317.80 mg; \u041a\u041b\u0406\u041d\u0406\u0427\u041d\u0406 \u0425\u0410\u0420\u0410\u041a\u0422\u0415\u0420\u0418\u0421\u0422\u0418\u041a\u0418 4.1 Therapeutic indications Treatment of cattle, sheep, goats, pigs, horses, foxes, minks and dogs from necrobacillosis, pasteurellosis, pneumonia, mastitis, metritis, wound infection, otitis media, septicemia, cellulitis; actinomycosis, blackleg; streptococcal septicemia of cattle, sheep […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/agroolkar.com.ua\/en\/production\/bytsynovet-5\/\" \/>\n<meta property=\"og:site_name\" content=\"O.L.KAR\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/agroolkar.com.ua\/\" \/>\n<meta property=\"article:modified_time\" content=\"2023-10-09T11:28:51+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/agroolkar.com.ua\/wp-content\/uploads\/2018\/02\/5912.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"700\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/agroolkar.com.ua\/en\/production\/bytsynovet-5\/\",\"url\":\"https:\/\/agroolkar.com.ua\/en\/production\/bytsynovet-5\/\",\"name\":\"Bicinovet-5 - 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