Antimicrobical agents for oral administration
Trimeroksin blister

Plano-cylinder tablets with a strip and a facet from white to light-grey colour almost without odor.

Release Type:
Blister – 10, 30 and 100 tablets.
Application:
Cattle - treatment of animals suffering from diarrhea, catarrhal bronchopneumonia, eymerioz, coliseptitsemiyu, salmonellosis, pasteurellosis, pneumonia, staphylococcal abscesses, caused by microorganisms which are sensitive to trimethoprim and sulfadimetoxine.

Plano-cylinder tablets with a strip and a facet from white to light-grey colour almost without odor.

 

Composition.

0,8 g of the drug contains the active ingredients:

-sulfadimetoxine – 250 mg;

-trimethoprim – 50 mg;

-excipients.

Pharmacological characteristic

Trimeroxine — has a wide range of bactericidal action.

Sulfadimetoxine – active against Gram negative and Gram positive bacteria(Staphylococcus spp, Streptococcus spp, Clostridium spp, Salmonella spp, E.coli, Pasteurella spp, Listeria monocytogenes, Corynebacterium spp, Klebsiella spp, Proteus spp, Bordetella spp ., Coccidia, Toxoplasma, ma Rickettsia), less active against Proteus. The mechanism of action is connected with PABA and competitive inhibition of digidropteroatsintetaze that leads to the synthesis disruption of tetrahydrofolic acid required for the synthesis of purines and pyrimidines.

Trimethoprim – a chemotherapy drug  which is active against Gram positive(Staphylococcus spp, Streptococcus spp, Clostridium spp, Corynebacterium spp. and others) and Gram negative bacteria(E. coli, Salmonella spp, Klebsiella spp, Proteus spp, Pasteurelia spp, Bordetella spp. etc.) It inhibits bacterial reductase, which converts degidrofolic acid to tetrahydrofolic acid, which is necessary for the synthesis of purines and nucleic acids. Thereby trimethoprim blocks one of the main metabolic processes of bacteria on the way of protein synthesis.

Application

Cattle – treatment of animals suffering from diarrhea, catarrhal bronchopneumonia, eymerioz, coliseptitsemiyu, salmonellosis, pasteurellosis, pneumonia, staphylococcal abscesses, caused by microorganisms which are sensitive to trimethoprim and sulfadimetoxine.

Horses – treatment of animals suffering from bronchopneumonia, dyspepsia, salmonellosis, pasteurellosis, urinary infections caused by microorganisms which are sensitive to trimethoprim and sulfadimetoxine.

Sheep – treatment of animals suffering from pasteurellosis, salmonellosis, coliseptitsemia, pneumonia, bacterial origin diarrhea caused by microorganisms sensitive to trimethoprim and sulfadimetoxine.

Pigs – treatment of animals suffering from pasteurellosis, colienterotoksemiyu, gastroenteritis, salmonellosis, coccidiosis, balantidioz, pleuropneumonia, dysentery, caused by microorganisms sensitive to trimethoprim and sulfadimetoxine.

Dogs, cats– treatment of animals suffering from pneumonia, mycoplasmosis, enterocolitis, salmonellosis, pasteurellosis, coccidiosis, isosporiasis, endometritis, mastitis, caused by microorganisms sensitive to trimethoprim and sulfadimetoxine.

Dosage

Per os, individually with food or water, either by group meal at the doses given in the table

 

Species

first day

2, 3, 4, 5 day

cattle, sheep, goats (including young animals )

1 tablet per 5 kg body weight

1 tablet per 10 kg body weight

horses, foals

1 tablet per 7 kg of body weight

1 tablet per 15 kg body weight

pigs, little pigs

1 tablet per 5 kg body weight

1 tablet per 10 kg body weight

Dogs, cats

1 tablet per 10 kg body weight

1 tablet per 20 kg body weight

 

Drug is applied daily for 5-10 days for animals which suffer from eymerioze, balantidioze, isosporiasis. In case of protozoozah –  treatment of animals  should be taken by three courses for a period of 5 days each. The interval between courses is 5-10 days.

 

Contraindications and Precautions

Do not use for animals which are hypersensitive to the active ingredients of the drug and also have problrems with liver, kidneys and  hemopoietic organs

Slaughter of animals for meat (cattle, sheep, goats, horses, pigs) is allowed in 4-5 days after the last application of the drug. Milk can be consumed in 4 days after the last drug application. In case the slaughter took place before allowed terms, meat should be utilize or fed to unproductive animals, according to the decision of the veterinary doctor.

Form of packaging

Blister – 10, 30 and 100 tablets.

Storage

In the dry, dark place with the temperature from 5 to 25 ° C.

Do not store together with food.

 

Expiration date– 2 years from the realease date.