The emulsion of white color , odorless and tasteless.
PHARMACOLOGICAL CHARACTERISTICS. Lerafen – anthelmintic broad-spectrum drug, consisting of active substances rafoxanide, fenbendazole and levamisole hydrochloride. The mechanism of action of rafoxanide is the inhibition of process of oxidative phosphorylation and mitochondrial synthesis of adenosine triphosphate (ATP), the change in the energy balance of parasite that causes the death of worms. Fenbendazol inhibits enzyme system of worms, which also leads to disruption of energy metabolism and causes the death of the parasites. The mechanism of action of levamisole hydrochloride is related to its effect on the neuromuscular system and inhibition of enzymes of parasites, leading to paralysis and death of worms.
Lerafen effective against mature trematode family Paramphistomatidae and their larvae (over 6 weeks of age). The drug is also active against mature trematode species Fasciola hepatica and Dicrocelium lanceatum; gastrointestinal and pulmonary nematodes: Bunostomum spp., Capillaria spp., Chabertia spp., Соореrіа spp., Dictyocaulidae spp., Gaigeria spp., Haemonchus spp., Nematodirus spp., Oesophagostomum spp., Ostertagia spp., Protostrondylus spp., Strongyloides spp., Тrichostrongylus spp., Trichuris spp. etc.; certain types of cestodes: Avitellina сеntripumctata, Moniezia ехpansa, Moniezia benedeni, Thysaniezia giardi) and larvae Oestrus ovis.
APPLICATION. For control of distomiasis (paramphistomatosis, dicroceliosis, fasciolasis), nematodosis of intestinal canal and lungs, as well as cestodiasis caused by certain types of cestodes of cattle, sheep and goats.
DOSAGE. treatment is carried out once before the morning feeding. The drug is administered orally mixed with warm water (25-30°C) using a bottle or in a mixture of 1.5-2 kg wet feed with doses:
cattle: dicroceliosis, fasciolasis – 0,75 ml / 10 kg of body weight, paramphistomatosis, nematodosis – 1 ml / 10 kg of body weight;
sheep, goats: diverse helminthosis – 0,75 ml / 10 kg of body weight.
CONTRAINDICATIONS. Do not use for down-calving and just calved cows, animals with clinical signs of disorder of the digestive system (atony forestomach, meteorism), depletion and infectious diseases.
Do not use in conjunction with bromsalanflukicide.
PRECAUTIONS. Before the mass treatment each serie of Lerafen previously need to be tested on small number of animals under which observe during the day.
Slaughter of animals for meat is permitted in 28 days, and the consumption of milk for human nutrition – in 7 days after the last use of the drug.
STORAGE. Dry, dark place at the temperature from 5°C to 25°C.
Shelf –life – 3 years from the date of manufacture