A clear, yellowish liquid with low specific smell.
DESCRIPTION. A clear, yellowish liquid with low specific smell.
PHARMACOLOGICAL CHARACTERISTICS. Burdi spot-on has a broad spectrum of antiparasitic actions, is active against larval and mature intestinal nematodes, including Toxocara canis, Toxocara cati, Toxascaris leonina, Ancylostoma spp., Uncinaria stenocephala, Trichuris vulpis, and cestodes, including Echinococcus granulosus, Echinococcus multilocularis, Diphyllobothrium latum, Dipylidium caninum, Multiceps multiceps, Taenia spp., Mesocestoides lineatus, and fleas Stenocephalides spp., lice Linognatus setotus, tongs Trichodectes canis, Sarcoptidae Sarcoptes canis, Otodectes cynotis, Notoedres cati and demodectic Demodex canis mites. After skin application drug is accumulated in the epidermis, hair follicles and sebaceous glands of animals, and ispartially absorbed from the site of application, enters the the system bloodstream, organs and tissues, causing prolonged antiparasitic effect.
Antiparasitic action of ivermectin is based on blockade of neural or neuromuscular transmission by acting on the gammaamino butyric acid (GABA), resulting in blockade of momentum transfer between excitatory interneurons and motor neurons of the ventral trunk parasite, and this leads to the defeat and death of the parasite.
The mechanism of action ofpraziquantelprovides depolarization of neuromuscular ganglionic blockers, infringement of glucose transport and microtubular function of all phases of development of cestodes, which causes a disturbance of innervation of muscle, paralysis and death of parasites.
Burdi spot-on bythe degree of influence on the body belongs to moderately hazardous substances, at recommended doses does not show local irritative effect, resorptive-toxic, embryotoxic, teratogenic and sensitizing actions. Is well tolerated by dogs and cats of various breeds and ages. After contact causes irritation of mucous.
APPLICATION. Prevention and treatment of nematodosis, cestodiasis, myiasis, ear mange, sarcoptic mange, notoedric mangeand demodicosis of dogs and cats.
DOSAGE. The drug is used by drip («Spot-on») application on undamaged dry skin.
Before application in tube-pipette break off tip and deploying hair, apply the drug on the skin of the animal in a place inaccessible to lick off (in the neck at the base of the skull).
In case of processing of large animals pipette contents put in 3-4 places.
Depending on body weight, use drug of different packaging at the following doses given in the table.
For the destruction of fleas, lice and tongs treatment of animals is carried out once, to prevent reinvasion – once a month throughout the season of insects activity. In order to prevent reinvasion of animals by fleas change litter or process it byinsecticide.
For treatment of ear mange drug is applied on the skin once. During treatment is recommended to clean the ear canal from exudate and scab, and with complicated otitis appoint antimicrobial and anti-inflammatory drugs.
If necessary, repeat the treatment after one month.
With the purpose of treatment ofsarcoptic mange and demodicosis dogs and cats notoedric mangedrug is used 2-4 times with intervals of 10-14 days; to prevent invasion – once a month. For dehelmintization of animals at nematodosis and cestodiasis drug is used for therapeutic purposes once, with preventive – once a quarter.
CONTRAINDICATIONS. Do not use to pregnant and lactating animals.
PRECAUTIONS. It isrecommendedto conduct complex treatment with application of etiotropic, pathogenetic and symptomatic medications.
The drug is not recommended to apply on wet or damaged skin.
It is not recommended to wash the animal during four days after treatment with the drug.
Do not use simultaneously with other antiparasitic drugs.
Do not stroke the animal and keep away from children for 24 hours after treatment with the drug.
STORAGE. Dry, dark, inaccessible to children and animals place away from food and feed away from heating appliances and fire, at temperature from 0°C to 25°C in a package ofproducer.
SHELF-LIFE – 1,5 year from the date of manufacture.