Antihelmintics
Closan 5% euro injection solution

Bottles sealed with gray rubber stopper, with an aluminium cap on top

Release Type:
Glass bottles of 10, 50, 100 and 250 ml.
Type of drug:
Antihelmintics
Application:
Prevention and treatment of cattle and small ruminants from the following diseases

СOMPOSITION

1 ml contains: closantel – 50 mg;

 

PACKAGING

Glass bottles of 10, 50, 100 and 250 ml.

Bottles sealed with gray rubber stopper, with an aluminium cap on top

 

 

DESCRIPTION. Clear thick yellow solution.

PHARMACOLOGICAL CHARACTERISTICS. ATCvet QP52A, anti-distomiasis, anti-nematodosis and anti-cestodiasis veterinary drugs (QP52AG09, clo­santel).

The active ingredient of the drug – closantel, antiparasitic agent, structurally derived salicylanilide that has a long ef­fect on endo- and ectoparasites.

Closantel blocks phosphorylation process (formation of ATP) in the body of parasites through interference in the process of transporting electrons, changing energy me­tabolism, resulting in the death of parasites.

Closantel has a wide range of actions, effective in the treatment of parasitic diseases of cattle and small rumi­nants caused by nematodes, trematodes and arthropods.

Closantel is rapidly absorbed after oral or intramuscular administration. Maximum concentration in the blood of sheep is reached after 8-24 hours after administration, the blood of cattle – 24-48 hours. The half-decomposi­tion is approximately 12-15 days.

Most part  of used closantel is concentrated in the lungs and kid­neys, and the main way of its metabolism is renewable deionization.

APPLICATION. Prevention and treatment of cattle and small ruminants from the following diseases:

cattle:

– fasciolosis (Fasciola hepatica, mature and late larval forms);

– nematodosis (adult and larval forms Bunostomum spp., Haemonchus сontortus, Haemonchus placei and Oesophagostomum radiatum);

– hypodermosis caused by the larvae of subcutaneous gadfly Hypoderma spp.;

sheep, goats:

– fasciolosis (Fasciola hepatica, mature and late larval forms);

– nematodosis (adult and larval forms Bunostomum spp., Haemonchus сontortus, Haemonchus placei and Oesophagostomum radiatum, Chabertia ovina);

– oestrosis (Oestrosis ovis).

DOSAGE. The drug should be given only by subcutaneous once at the doses given in the table. It is recom­mended to inject the  the dose volume  in few different spots.

CONTRAINDICATIONS. Do not use with other  antiparasitic chlorine-organic drugs. Do not use for dairy and pregnant cattle in the last trimester of pregnancy.

PRECAUTIONS. Slaughter of animals for meat is per­mitted in 28 days, using milk for human nutrition – 14 days after the drug usage. Slight inflammation in the in­jection site is possible, but it disappears independently in two – three days after injection.

Some breeds of cattle (Charolais and its hybrids) are par­ticularly sensitive to the drug, approximately 2% of the animals had anaphylactic reactions after the injection.

STORAGE. Store in a cool, dry, dark place at the tem­perature from 5 to 25°C.

Expiration date – 2 years from the date of manufacture.

Type animals

Diseases

The dose by

the active substance

Dose

Cattle fasciolosis

nematodosis

hypodermosis

2,5 mg closantel per kg of body weight

2,5 mg closantel per kg of body weight

5 mg closantel per kg of body weight

0,5 ml/10 kg of body weight

0,5 ml/10 kg of body weight

1 ml/10 kg of body weight

Sheep, goats fasciolosis

nematodosis, oestrosis

5 mg closantel per kg of body weight

2,5 mg closantel per kg of body weight

1 ml/10 kg of body weight

0,5 ml/10 kg of body weight