Injection antimicrobials
KETOFUR 200
Release Type:
The vials are closed with rubber stoppers under an aluminum rim on 10, 20, 50, 100, 200 ml. Secondary packaging – the carton.
Type of drug:
Application:
(Русский) Лечение коров, больных некробактериозом и эндометритом, а также при заболеваниях органов дыхания, вызванных микроорганизмами, чувствительными к цефтиофуру.

Description

Oily suspension from yellow to brownish-yellow color with a light odor of ingredients; it laminates during storage.

Compound

1 ml of medicine contains such active  substances:

ceftiofur hydrochloride – 50 mg;

ketoprofen – 150 mg.

Pharmacological properties

ATC vet classification code QJ01- antibacterial veterinary medicine for  systemic application. QJ0DD99 – ceftiofur, combinations.

Ceftiofur belongs to the group of cephalosporin of the third generation. It is active against gram-positive and gram-negative bacteria, including strains that produce beta-lactamase, and some anaerobic bacteria: Escherichia coli, Pasteurella haemolytica, Pasteurella multocida, Haemophilus somnus, Actinobacillus pleuropneumoniae, Haemophilus parasuis, Salmonella cholerasuis, Streptococcus suis, Streptococcus zooepidemicus, Pasteurella spp, Staphylococcus spp., Actynomyces pyogenes, Salmonella typhimurium, Streptococcus agalactiae, S. dysgalactiae, S.bovis, Klebsiella spp., Citrobacter spp., Enterobacter spp., Bacillus spp., Proteus spp., Fusobacterium necrophorum і Porphiromonas assacharolytica (Bacteroides melaninogenicus). The mechanism of the antibiotic action is to suppress the synthesis of the wall of bacteria’s cell.

Ketoprofen – NSAIA based on propionic acid. It has anesthetic, anti-inflammatory and antipyretic effect. The mechanism of the action connected with suppressing the synthesis of prostaglandins at the level of cyclooxygenase.

In addition, ketoprofen inhibits lipoxygenase, has anti-bridikinin activity, stabilizes lysosomal membranes, causes significant inhibitory activity of neutrophils. Ketoprofen is a double inhibitor of inflammation, blocking the action of cycloxygenase and lipoxygenase and thus preventing the formation of prostaglandins and leukotrienes. Ketoprofen is a painkiller that affects the central and peripheral nervous system. Its effect is to directly suppress the action of bradykinin, vasodilators and a mediator of pain.

After parenteral administration, ceftiofur is rapidly absorbed into the injection site and penetrates into all animal tissues. Its maximum concentration in plasma is observed in an hour, which is contained at the therapeutic level up to 24 hours, depending on the species of animals. Ceftiofur in the body is rapidly metabolized to the formation of desfuroilceftiofur, which has an activity equivalent to ceftiofur, relative to bacteria. This active metabolite is back ligated to plasma proteins and accumulates in the infection center, while its activity is not reduced in the presence of necrotic tissues.

The removal of the antibiotic occurs mainly with urine and feces.

Ketoprofen is quickly absorbed. Over 98% binds to plasma proteins and accumulates in inflamed tissues. Peak plasma levels in cows (8,025 ± 1,9 μg / ml) are achieved in less than one hour after administration. Significant concentrations of ketoprofen are found in synovial fluid and its level is higher here than in plasma, and the half-life is 2-3 times higher than in plasma. Ketoprofen is metabolized in the liver to small biologically active metabolites, and 90% is excreted in the urine as compounds of glucuronide.

Usage

Cow’s treatment which are suffering from necrobacteriosis and endometritis, respiratory organs diseases caused by microorganism sensitive to ceftiofur.

Dosage

Once a day in dose of  1 ml on  50 kg of animal’s body weigh (1 mg of   ceftiofur and 3mg of ketoprofen on 1 kg of animal’s body weigh), intramuscularly. In case of respiratory organs diseases the course of treatment is – 3-5 days, in case of necrobacteriosis – 3 days, during endometritis – 5 days.

Before application you should shake the vial with the medicine and heat it for 36 ° С.

Contraindication

Don’t apply to animals with high sensibility to the active substances or to any excipient.

Don’t apply to animals with severe disorder of kidney and liver function.

Don’t apply to animals at the age less than 6 weeks.

Don’t apply to animals with hemopoiesis disorder, gastrointestinal tract ulcers, kidney and liver diseases.

Don’t apply to animals in the state of hypotension, hypovolemia and dehydration.

Don’t apply at the same time with other non-steroidal anti-inflammatory medicines, diuretics or anticoagulants, as well as tetracyclines, chloramphenicol, macrolides and lincosamides.

Warning

Slaughter of animals for meat is allowed after 8 days after the last application of the medicine.

The milk elimination period is 0 hours. Obtained, before the specified date, the meat is utilized or fed to unproductive animals, depending on the conclusion of the doctor of veterinary medicine.

Form of release

The vials are closed with rubber stoppers under an aluminum rim on 10, 20, 50, 100, 200 ml. Secondary packaging – the carton.

Storage

Dry, dark, not available for children place at the temperature from 10 ° С to 25 ° С.

Expiration date – 2 years.

After opening of the medicine it should be used during 7 days and stored in a dry, dark place at the temperature from 4 ° C to 8 ° C.

For applying in veterinary medicine!