Oily suspension from yellow to brownish-yellow, with a slight smell of constituents, with storage is stratified.
1 ml of the drug contains active substances:
ceftiofur hydrochloride – 50.0 mg;
Ketoprofen – 50.0 mg.
ATC vet classification code QJ01- antibacterial veterinary drugs for system use. QJ0DD99 – ceftiofur, combinations.
Ceftiofur belongs to the third generation of cephalosporins. It is active against gram positive and gram negative bacteria, including strains that produce beta-lactamases, and some anaerobic bacteria: Escherichia coli, Pasteurella haemolytica, Pasteurella multocida, Haemophilus somnus, Actinobacillus pleuropneumoniae, Haemophilus parasuis, Salmonella cholerasuis, Streptococcus suis, Streptococcus zooepidemicus , Pasteurella spp, Staphylococcus spp., Actinomyces pyogenes, Salmonella typhimurium, Streptococcus agalactiae, S. dysgalactiae, S. bovis, Klebsiella spp., Citrobacter spp., Enterobacter spp., Bacillus spp., Proteus spp., Fusobacterium necrophorum and Porphiromonas assacharolytica (Bacteroides melaninogenicus). The mechanism of action of the antibiotic is to suppress the synthesis of the cell wall of bacteria.
Ketoprofen – Propionic acid-based NSAIDs. It has an analgesic, anti-inflammatory and antipyretic effect. The mechanism of action is associated with inhibition of the synthesis of prostaglandins at the level of cyclooxygenase. In addition, ketoprofen inhibits lipoxygenase, has anti-bradykinin activity, stabilizes lysosomal membranes, causes significant inhibitory activity of neutrophils. Ketoprofen is a dual inhibitor of inflammation, blocking the action of cycloxygenase and lipoxygenase and thus preventing the formation of prostaglandins and leukotrienes.
Ketoprofen is a painkiller that affects the central and peripheral nervous system. Its effect is to directly suppress the action of bradykinin, vasodilator and pain mediator.
After parenteral administration, ceftiofur is rapidly absorbed from the injection site and penetrates into all animal tissues. Its maximum plasma concentration is observed in an hour, which is maintained at the therapeutic level up to 24 hours, depending on the species of animals. Ceftiofur in the body is rapidly metabolized to the formation of desfuroilceftiofur, which has an activity equivalent to ceftiofur, relative to bacteria. This active metabolite is back ligated to plasma proteins and accumulates at the center of infection, while its activity is not reduced in the presence of necrotic tissues.
The removal of the antibiotic occurs mainly with urine and feces.
Ketoprofen is rapidly absorbed. Connected to plasma proteins. Significant concentrations of ketoprofen are found in synovial fluid, and its level is higher than in plasma, and the half-life is 2-3 times higher than in plasma. Ketoprofen is metabolised in the liver to small biologically active metabolites, and 90% is excreted in the urine as compounds of glucuronide.
Treatment of pigs in respiratory diseases caused by microorganisms (Haemophilus somnus, Actinobacillus pleuropneumoniae, Salmonella cholerasuis and Streptococcus suis), sensitive to ceftiofur, as well as in the treatment of pigs with MMA syndrome (metritis-mastitis-agalactia), conditions caused by acute and chronic forms inflammatory processes of the musculoskeletal system.
Intramuscularly once daily in a dose of 1 ml per 16 kg of body weight of the animal (3 mg ceftiofur and 3 mg ketoprofen per kg body weight of the animal) for 3 days.
Before use, the vial with medicinal product should be shaken and heated to 36 ° C.
Do not apply to animals with a high sensitivity to active substances or to any of the excipients. Do not mix the drug with other drugs in one syringe.
Do not apply to animals with acute renal failure.
Do not apply to animals up to 6 weeks old.
Do not apply to animals with a violation of hemopoiesis, ulcers of the gastrointestinal tract, diseases of the kidneys and liver. Do not apply to animals in the state of hypotension, hypovolemia and dehydration.
Do not use at the same time as other non-steroidal anti-inflammatory, diuretic or anticoagulant drugs, as well as with tetracyclines, chloramphenicol, macrolides, and linzamides.
Slaughter of animals for meat is allowed 12 days after the last application of the drug. Obtained, before the specified period, the meat is utilized or fed to unproductive animals, depending on the conclusion of the doctor of veterinary medicine.
Form of release
The vials are closed with rubber stoppers under an aluminum rim for 100 ml. Secondary packaging – box.
A dry, dark, inaccessible place for children at a temperature of 10 ° C to 25 ° C.
The expiration date – 2 years.
After the first selection from the vial, the drug should be used within 15 days, provided it is stored in a dry, dark place at a temperature of 4 ° C to 8 ° C.
For applying in veterinary medicine!