Hormones, contraceptives

injection solution                                                                

Composition 

1 ml of the product contains: Dexamethasone sodium phosphate – 2,64 mg (equivalently 2 mg of dexamethasone).

Clinical pharmacology 

Dexaguard is a glucocorticosteroid drug, that has anti-inflammatory, antiallergenic, desensitizing, antishock, immunodepressive and antiproliferative actions. Dexamethasone and its derivatives are synthetic glucocorticoids. Used for its anti-inflammatory or immunosuppressive properties and ability to penetrate the CNS, dexamethasone is used alone to manage cerebral edema and with tobramycin to treat corticosteroid-responsive inflammatory ocular conditions. Dexamethasone is a glucocorticoid agonist. Unbound dexamethasone crosses cell membranes and binds with high affinity to specific cytoplasmic glucocorticoid receptors. This complex binds to DNA elements (glucocorticoid response elements) which results in a modification of transcription and, hence, protein synthesis in order to achieve inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of dexamethasone are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Dexamethasone is approximately 77% protein bound in plasma. The majority of protein binding is with serum albumin. Dexamethasone does not significantly bind to corticosteroid binding protein.

Application 

Metabolic process: bovine ketosis, postpartum toxemia of sheep and breeding pigs.

Non-infectious inflammatory processes: arthritis, periarthritis, tendovaginitis, bursitis, dislocations, inflammation of muscles, bones and tendons.

Acute infectious diseases (acute mastitis, metritis, pneumonia), in combination with appropriate antibacterial therapy.

Allergic conditions, such as asthma, allergic skin lesions (eczema, hives, itching, etc.), laminitis in horses and cattle, snake bites.

Stress and state of shock;

Toxemia during the last stage of pregnancy (within 2-4 days).

Dosage 

IV, IM or SC (dogs and cats):

– cattle, horses: 5-10 ml per 400 kg bwg. Calving initiation – during a week before calving in a dose of 2,5 ml per 100 kg bwg;

 – pigs: 1,5 ml per 50 kg bwg;

– sheep, goats, calves: 1-2 ml per 50 kg bwg. In the case of postpartum toxemia and for lambing initiation: 6 ml of the product per 50 kg bwg;

– dogs, cats: 0,25-0,5 ml per 5 kg bwg.

If it’s necessary, apply the again: dogs and cats spaced 2 days; other animals – spaced 3-4.

In the complex of anti-shock therapy, the drug: slowly injection of a ten-fold anti-inflammatory dose, again after 8-12 hours.

Intra-articular application: depending on the affected area and body weight of the animal – from 0.25 to 4 ml.

Contraindications 

Hypersensitivity to the drug, fungal infection, active tuberculosis, diabetes mellitus, systemic infections, arterial hypertension, acute disorders of higher nervous activity, pregnancy, ulcerative lesions of the stomach and / or intestines, viral diseases, osteoporosis, Itsenko-Cushing’s syndrome, hypersensitivity to the components of the drug.

Side effects

Water and sodium retention, loss of potassium and calcium, hypertension, muscle weakness, osteoporosis, ulcer with possible subsequent perforation and bleeding, pancreatitis, wound healing, convulsions, dizziness, development of the Cushing’s syndrome, violation of the sexual cycle, manifestations of latent sugar diabetes, allergies, infectious diseases associated with the immunosuppressive effect of the drug. Inhibition of adrenal cortex function.

In the case of long-term treatment (more than 2 weeks), the development of functional adrenal insufficiency, diabetes, impaired secretion of sex hormones is possible. Secondary adrenal cortex can be caused due to the abrupt cancellation of corticosteroids and can be minimized by a gradual dose reduction.

Withdrawal period 

Meat – 14 days

Meat, received till indicated time, must be fed to fur-bearing animals or used for П meat and bone meal production.

Milk – 2 days

Milk, received till indicated time, can be fed to the animals after boiling

How supplied 

Glass bottles, closed with rubber corks under aluminium rolling up per 50 and 100 ml.

Storage 

Dry, dark, childproof place at temperature n.a. 25 °С.

Shelf life is 2 years. After the first opening it must be used during 14 days.