Injection antimicrobials
Benzylpenicillin

(for EXPORT sales)

DESCRIPTION. Crystalline powder, white or nearly white.

PHARMACOLOGICAL CHARACTERISTICS. Benzylpenicillin sodium salt sterile is a bactericidal antibiotic that belongs to a group of natural penicillins. The agent inhibits the formation of peptide bonds by inhibition of transpeptidase, interrupts the later stages of synthesis of peptidoglycane of the cell membrane, leading to lysis of divided microbial cells.

Drug is active against gram-positive bacteria, including Streptococcus spp., Staphylococcus spp., Bacillus spp., Listeria (L. monocytogenes), Erysipelothrix (E. rhusiopathiae), most corynebacteria and anaerobic bacteria (actinomycetes, Peptostreptococcus spp., Clostridium spp.), spirochetes (Treponema spp., Borrelia spp., Leptospira spp.). Most gram-negative bacteria, protozoa, viruses, fungi, and rickettsia are not sensitive to the agent. Among  gram-negative bacteria sensitive to the agent only Neisseria spp., Pasteurella multocida and  H. dugreyi.

APPLICATION. Treatment of cattle, sheep, goats, pigs, horses, fur animals (foxes, polar foxes, minks) dogs of  necrobacillosis, pasteurellosis, pneumonia, mastitis, metritis, traumatic fever, otitis media, urinary tract infections, septicemia, abscesses, actinomycosis, blackleg, streptococcal septicemia of cattle, sheep and goats, horses strangles, stachybotryotoxicosis, streptococcosis, staphylococcus infectious, stomatitis, rhinitis, plague of dogs and fur animals, erysipelas and other diseases caused by pathogens susceptible to benzylpenicillin.

DOSAGE. Solution of the benzylpenicillin sodium salt prepare immediately before application.

Contents of the flacon dissolve in 1-3 ml of sterile water for injection or isotonic sodium chloride solution or 0.5% solution of novocaine. The agent is injected intramuscularly with intervals of 4-6 hours at doses given in the table.

The course of treatment is 4-7 days, at severe disease – 7-10 days. The powder can also be used as a powder on the surface of the wound.

CONTRAINDICATIONS. Hypersensitivity to agents of the penicillin group or novocaine. In case of allergic reactions animals are injected with antiallergic drugs (norepinephrine or epinephrine, 10% solution of calcium chloride, diphenhydramine). Penicillin is highly toxic to guinea pigs, hamster.

PRECAUTIONS. Slaughter of animals for meat and milk for people is allowed in respectively, 4 and 2 days after the last application of the drug. Received by the deadline meat and milk utilize or fed to unproductive animals, according to a conclusion of a doctor of veterinary medicine.

STORAGE. Dry, dark, unreachable for children place at temperature from 5°C to 25°C.

SHELF LIFE – 3 years from the date of manufacture.